Following a recent survey by the ISCB of its members' international travel experiences, PLoS Computational Biology discusses the visa difficulties that hinder free international collaboration, conferences and job opportunities.
Based on the experiences of the ISCB Student Council, the latest addition to our Ten Simple Rules Collection offers invaluable tips on how to plan, organize and stage a successful scientific meeting of any size.
McIntosh, Kovacevic & Itier demonstrate that while behavior and responses become less variable as we mature into adults, variability in brain signals, or "noise", actually increases. This variability, indicative of enhanced neural complexity, allows the brain to operate at an optimal level.
The authors use a computational approach to simulate the behavior of a model signal transduction module (a kinase cascade) in the presence of scaffolding proteins, revealing mechanisms for how scaffolds can dynamically regulate the timing of cell signaling.
Kim, Lee & Levy present a model which incorporates each patient's anti-leukemia immune response. It offers a feasible, low-risk, clinical approach to enhancing the effects of imatinib treatment using "cancer vaccines" created from pre-therapy blood taken from the patients themselves.
Image credit: CDC/Stacy Howard
PLoS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is the official journal of the International Society for Computational Biology.
E-mail Alerts
RSS (What is RSS?)
Join PLoSRead the PLoS Blog 
and contribute your views on scientific research and open-access publishing.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.
